A novel transcatheter
LAA elimination system

Complete LAA elimination
without implant device

The clinical need is huge and growing

Millions

of patients worldwide suffer from
Non-Valvular Atrial Fibrillation
(NVAF), a life-threatening heart
rhythm disease

X5

increased risk of stroke
for NVAF patients

LAA – Left Atrial Appendage    LA – Left Atrium AF – Atrial Fibrillation

LAA occlusion solutions aim to decrease stroke risks and are progressively replacing other stroke prevention therapies
DRT and PDL are
inherent risks in current
LAA occlusion solutions

Device Related
Thromboembolism (DRT)
Caused by foreign material left
in the LA increases risk of stroke
by 5 fold

Peri Device Leakage (PDL)
Evidence shows even small
leaks are significant and
increase risk of stroke by 2 fold

The Append Transcatheter System

A sophisticated yet simple vacuum solution for
inversion and ligation of the LAA tissue
Without implanting any device in the heart, Append is
poised to disrupt the LAA occlusion market with a
proprietary vacuum system, eradicating DRT and PDL risks
while providing a transcatheter solution that universally fits
the widest range of anatomies.
No device in the heart
No device in the heart
Fits to the widest
range of anatomies
Fast procedure
No DRT
No PDL

Management Team

Nadav Agian

BSc, MBA | CEO

Liz Zinger

MSc | VP RA/QA & clinical

Shay Raviv

BSc, MBA | VP R&D

Yafit Keret

CPA, MBA | CFO

Haim Danenberg

MD | CMO
Interventional cardiologist

Board of Directors

Shlomi Nachman

Independent Director

Shai Policker

MEDX Xelerator LP

Dudi Klein

ALIVE HealthTech Fund

Nate Harrington

Philips Venture

Nadav Agian

Append CEO

Zachi Berger

Founder and Observer

Advisory Board

Leonid Sternik | MD

Inventor and cardiac surgeon
Sheba Medical Center

Horst Sievert | MD

Interventional cardiologist
CVC Frankfurt

Vivek Reddy | MD

EP specialist
Mount Sinai, NY

Charanjit S. Rihal | MD

Interventional cardiologist
Mayo Clinic, Minnesota

Ron Waxman | MD

Interventional cardiologist
Medstar Health Center
Washington DC

Prof. Rafael Beyar

Former Director and CEO of
Rambam Health Care Campus

Contact us