The clinical need is huge and growing
Millions
of patients worldwide suffer from
Non-Valvular Atrial Fibrillation
(NVAF), a life-threatening heart
rhythm disease
Non-Valvular Atrial Fibrillation
(NVAF), a life-threatening heart
rhythm disease
X5
increased risk of stroke
for NVAF patients
for NVAF patients
LAA – Left Atrial Appendage LA – Left Atrium AF – Atrial Fibrillation
LAA occlusion solutions aim to
decrease stroke risks and are
progressively replacing other
stroke prevention therapies
DRT and PDL are
inherent risks in current
LAA occlusion solutions
inherent risks in current
LAA occlusion solutions
Device Related
Thromboembolism (DRT)
Caused by foreign material left
in the LA increases risk of stroke
by 5 fold
Peri Device Leakage (PDL)
Evidence shows even small
leaks are significant and
increase risk of stroke by 2 fold
The Append Transcatheter System
A sophisticated yet simple vacuum solution for
inversion and ligation of the LAA tissue
inversion and ligation of the LAA tissue
Without implanting any device in the heart, Append is
poised to disrupt the LAA occlusion market with a
proprietary vacuum system, eradicating DRT and PDL risks
while providing a transcatheter solution that universally fits
the widest range of anatomies.
poised to disrupt the LAA occlusion market with a
proprietary vacuum system, eradicating DRT and PDL risks
while providing a transcatheter solution that universally fits
the widest range of anatomies.
No device in the heart
No device in the heart
Fits to the widest
range of anatomies
range of anatomies
Fast procedure
No DRT
No PDL
News & Updates
Advisory Board
Leonid Sternik | MD
Inventor and cardiac surgeon
Sheba Medical Center
Sheba Medical Center
Horst Sievert | MD
Interventional cardiologist
CVC Frankfurt
CVC Frankfurt
Vivek Reddy | MD
EP specialist
Mount Sinai, NY
Mount Sinai, NY
Charanjit S. Rihal | MD
Interventional cardiologist
Mayo Clinic, Minnesota
Mayo Clinic, Minnesota
Ron Waxman | MD
Interventional cardiologist
Medstar Health Center
Washington DC
Medstar Health Center
Washington DC
Prof. Rafael Beyar
Former Director and CEO of
Rambam Health Care Campus
Rambam Health Care Campus